Would calcified pleural plaques look the same as melanoma metastasis on a regular CT scan?

No, they would. not look alike. Calcified plaques are very dense, melanoma density is often greater than normal soft tissue, but far below calcium.

Related Questions

My father has metastatic melanoma, 1 lymph node involvement. Pet scan and CT scan shows no other metastasis at this time. Does this mean he is cured?

I am sorry... . To hear about your father. Melanoma is a horribly unpredictable cancer. It can show up six months or six years after the original treatment and can be literally anywhere in the body. Unfortunately there are no studies that can show microscopic disease. I advise my cancer patients to give their immune system the best chance to do its job by eating healthy, getting enough sleep, and stay fit. Read more...
Melanoma... Melanoma is a very tricky disease and must be followed closely. It can metastasize to odd places. It is good news that only 1 lymph node is seen on pet/ct rather than many lymph nodes but one should note that micrometastases or very small lesions may be below the resolution of pet imaging. Read more...