Hiya, what are the causes of sickle cell anemia? I know it is inherited but I need it explained in a way that can tell me the causes of gene mutation.

Gene mutations. are random. The sickle gene confers some resistance to malaria due to the abnormal configuration of hemoglobin. Sickle trait/sickle cell anemia is most prevalent in populations where malaria is or was endemic. It is likely that the mutation conferred some competitive advantage due to its antimalarial effects and was promulgated through natural selection.
2 doses of gene. SSA occurs when the baby gets a sickle gene from both parents.This gene causes the cell to deform (sickle) in some conditions in the body.These cells break down easier resulting in anemia.If they only get 1 sickle gene the good 2nd gene keeps it from deforming.The mutation was random and occurred 10's of thousands of years ago. Being a carrier of one gene makes you less likely to die from malaria.

Related Questions

Could you tell me what gene is affected by sickle cell anemia?

The beta globin gene. Hemoglobin is a complicated molecule in red blood cells that carries oxygen from the lungs to the rest of the body. It contains 4 protein chains, 2 Alpha chains and 2 beta chains. Sickle cell disease is caused by specific mutation in the beta globin gene. We each have two beta globin genes. If one has the s mutation you have sickle trait; if both have the s mutation you have sickle cell anemia. Read more...
Beta globin . The beta globin gene is on chromosome 11. The gene mutation is a Adenosine to thymine base substitution in the gene that changes the normal glutamic acid in position 6 of beta globin protein with valine. Read more...

Can you please tell me genetics of sickle cell anemia?

Inherited disease. Sickle cell disease is genetic and is present at birth. It is inherited when a child receives two sickle cell genes—one from each parent. This disease is more common in blacks (people of african heritage). Sickle cell trait occurs when one sickle cell gene (“s”) is inherited from one parent and one normal gene (“a”) from the other. Those with trait are "carriers" and are often asymptomatic. Read more...
Sickle cell disease. Occurs when both copies of their beta globin gene (one received from each parent) harbor a mutation in codon 6 that changes the encoded Amino Acid from glutamate to valine. Patients can't make normal hemoglobin consequently, and instead can only make hgbs. If you inherit one normal and one beta-s, you can make some normal (hgba) and some hgbs. The normal hgba limits sickling. This is sickle trait. Read more...

Can you explain to me how mutation take place in sickle-cell anemia?

Important gene... Sickle cell anemia is caused by a mutation in the gene that tells your body to make hemoglobin. Hemoglobin allows red blood cells to carry oxygen from your lungs to all parts of your body. In sickle cell anemia, the abnormal hemoglobin causes red blood cells to become rigid, sticky and misshapen. These abnormal red blood cells lead to the various symptoms of the disease. Read more...

What chromosome carries the gene for sickle cell anemia?

Chromosome No. 11. Point mutation at beta-globin gene located at chromosome no. 11 results in production of defective hemoglobin, sickle hemoglobin. Read more...
Chromosome 11. The "beta globin gene cluster" is located on the shorter arm of chromosome 11. The mutation that causes sickle cell anemia occurs in the red area on the chromosome, in the beta globin gene. Read more...

Help plz! Can sickle cell anemia be cured with gene therapy?

Not as far I know. This may be the future. But as of right now, I am not aware of gene therapy for sickle cell disease. The only cure for it at the moment is bone marrow transplant. . Read more...

Help please! Is gene therapy a permanent cure for sickle cell anemia?

In theory yes. As sickle cell anemia is a genetic disease, correction of the gene defect by stem cell transplantation or gene therapy would theoretically correct the genetic defect. Gene therapy is experimental at this time. Stem cell transplantation is more common, but is limited by the availability of suitable tissue matched donors. In either case, correction of the genetic defect will not fix prior strokes. Read more...
Maybe. Gene therapy could be a permanent cure for sickle cell anemia, but this is still an experimental trial and the success depends largely on the number of stem cells that are gene corrected to make normal hemoglobin. At this point, the only curative therapy for scd is bone marrow transplant. Read more...

How does gene therapy be used to cure someone with sickle cell anemia?

Replace gene. Gene therapy could be used to transfer a new replacement normal gene to cells producing red blood cells. That is how gene therapy would work however there are no approved gene therapy treatments for sickle cell anemia. Read more...

What are the types of gene defects in sickle cell anemia?

Several. There are several genetic defects that lead to sickle cell anemia. They all lead to a change in the 6th Amino Acid in the beta-globin chain in which valine is substituted for glutamic acid. At least 5 different dna mutations have been identified that all lead to the same Amino Acid substitution, and thus, sickle cell anemia. Read more...

Sickle cell anemia:is this birth defect only due to genetics?

Yes. It is a defect present from birth, yes. Would i call it a birth defect, no. It is a genetically derived abnormality in the metabolism of hemoglobin that results in sickling of the red cells under some circumstances. As a metabolic disease, it is inherited in a similar fashion to pku or cystic fibrosis. The term birth defect is more appropriate for a kid with malformation of an organ or body part. Read more...