Clindamycin. It is better not to drink alcohol on the days you are on antibiotics as alcohol can affect clindamycin's pharmacology as well as add to side effects of clindamycin . If abstinence not practical then only light drinking after 4 hours or more can be ok. Medicine is eliminated by gall bladder and kidneys and chronic alcohol use can decrease function of these as well. .
No major problem, if. NO major problem if you're talking about a small amount of alcohol, a glass of wine or a beer.; Clindesse is a topical anti-bacterial for vaginitis, and is not heavily absorbed systemically. Thus drinking in moderation should not have any significant effect on the treatment and should not induce problematic side effects.