I took Zoloft at eleven o'clock yesterday morning and I have a migraine​. Is it safe to take an ibuprofen or an Excedrin without horrible side effects?

Be careful . Avoid ibuprofen and all NSAIDs, also compounds containing aspirin as excedrin migraine, all those can interact with zoloft and cause increased risk of bleeding or CNS symptoms, if used without caution. You may want to use preparations like excedrin tension headache which contains acetaminophem and caffeine for now, no aspirin in it, and on your next doctor's visit address this issue, good luck.