I got 2 doses of fluconazole for yeast infection that caused skin irritation from vulva to anus also on two OTC creams. How long will skin peel/stop?

1-2 wks? Provided that the fungal infection is the cause for the irritation. We need to know also what kind of OTC creams you are using since some of them may actually irritate your skin further. If the yeast infection is not the cause, your skin will not heal until the actual cause has been taken of.