I understand that monoclonal gammopathy can cause a high CRP. As a matter of interest, does it typically elevate the WBC as well?
Neither. Neither an elevated CRP nor elevated WBC are part of the pathology in uncomplicated monoclonal gammopathy.
No. No the wbc count is usually not elevated.
I understand that uncomplicated monoclonal gammopathy does not raise the WBC & CRP. But can MGUS lead to more serious conditions that do elevate both WBC & CRP? Would there be ANY other pathological data to look for if a worse condition comes about?
MGUS. http://www.mayoclinic.org/diseases-conditions/mgus/symptoms-causes/dxc-20199538 Regular follow up with a hematologist would identify progression. Check your urine intermittently for proteins; light chains, Bence Jones proteins and check renal function. Today there are many treatments for the varying sequela. Read more...
What are possible causes of highly elevated ImM levels with low ImG levels with no monoclonal gammopathy present?
Get a consult. A specialist immunologist may be able to address this. I'm concerned right away about a variant of relatively mild immunodeficiency in which there's difficulty switching from IgM to IgG. Rather than trouble you with the details, let me simply suggest that this belongs in the hands of a subspecialist. Best wishes. Read more...