My ANA Hep-2 Titer is >1280 Titer 1 and standard is <80 Titer 1. pattern is Centromere. I have lupus. Just how bad is this result? Common?

Lab tests. Both of these tests may be suggestive of lupus or other autoimmune conditions. However, the lab test are just 1 component of the overall assessment and does not by itself makes the diagnosis of lupus. I recommend seeing a rheumatologist and would be happy to consult if needed.