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A dermatologist will help you.
She will be interested in your activities and job. Wet work? Food handling? Hands exposed to cold? What have you tried so far? Meanwhile make sure you have warm gloves when you go out or drive. Get a ceramide cream such as Eucerin in a jar or pump bottle. At bedtime soak hands for a long time in hot water, then rub in the cream. Repeat in AM. Use chapstick on cracks.