Hepatocellular carcinoma. All spleen and partial liver resection. Later, secondary systemic cancer metastasis. Any targeted therapy or immunotherapy?

Yes, for both. Hepatocellular Carcinoma is commonly treated with Sorafenib which is a type of targeted therapy. This is a good choice of treatment in case you have not yet received this drug. Immunotherapy using PD-1 inhibitors has also shown some modest evidence of benefit although it is not yet FDA approved for this indication. Ask your oncologist to guide your treatment further.