Can beta blockers (labetalol) make it hard to lose weight, or cause weight gain?

Known side effect. According to the FDA, wt gain is a side effect of most beta-blockers as listed in the package insert (PI- the little white paper that comes with all drugs). In those who gained wt (not everyone!), the average is about 4 lbs. Newer beta-blockers like Coreg (Carvedilol) have less weight gain, on average. TTYD, however, about your concerns because protective effect of BB may outweigh effect of wt gai.