What's the best medication for extreme snappiness, and extremely tired very irritable. I've tried Prozac, Wellbutrin etc.?

Irritable. A medication is not the only way to fix this. Please think holistically. See doc to make sure you do not have medical issues such as thyroid or other hormone imbalances. How is your diet and exercise level? Are there decisions you need to make? Consider seeing a mental health pro for support and clarification. Peace and good health.