Hello. I have a quick question regarding possible drug interactions. Do the antidepressants Zoloft, Viibryd, and Clonidine make hormonal birth control (Tri Cyclen Sprintec) less effective?

Drug interaction. person of unknown age gender medical Hx or medication Hx asks: I have a quick question regarding possible drug interactions. Do the antidepressants Zoloft, Viibryd, and Clonidine make hormonal birth control (Tri Cyclen Sprintec) less effective? ANS: i would go to Drugs.com and look up drug interactions. It will depend on how each is metabolized in your body. I would ask the team prescribing them.