6 doctors weighed in:
Can endometriosis cause cancer?
6 doctors weighed in

Dr. Pavel Conovalciuc
Family Medicine
3 doctors agree
In brief: No
Endometriosis is not a precancerous condition, although, it does act like a cancer would, though.
It may spread around the abdominal cavity, but it doesn't cause death or intoxication like cancer would. It is one of the major causes of infertility and chronic abdominal and/or pelvic pain.

In brief: No
Endometriosis is not a precancerous condition, although, it does act like a cancer would, though.
It may spread around the abdominal cavity, but it doesn't cause death or intoxication like cancer would. It is one of the major causes of infertility and chronic abdominal and/or pelvic pain.
Dr. Pavel Conovalciuc
Dr. Pavel Conovalciuc
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1 comment
Dr. Robert Albee
Much debate continues to surround the cancer-endometriosis link, with researchers calling the “histogenesis of endometriosis and endometriosis-associated ovarian cancer [one of the] most mysterious aspects of pathology.” [Kajihara et al] Current evidence is insufficient to draw any definitive conclusions whether this association represents causality or the sharing of similar risk factors and/or antecedent mechanisms. [Munksgaard, Blaakaer] Nevertheless - it has been well established that the disease IS indeed associated with an increased risk for non-Hodgkin lymphoma and certain malignant tumors, notably ovarian, with 15-40% of endometrioid ovarian carcinoma cases being associated with endometriosis. Based on this frequent association, many reports implicate endometriosis as a precursor lesion to ovarian cancer. The risk of ovarian cancer among those patients with endometriosis is higher than those without the disease by 30-40%. One analysis [Bell, Kurman] of benign ovarian endometrioid tumors found frequent co-existence of endometriosis and endometrioid neoplasms, supporting a genetic link between the two. In an estimated 60% of endometriosis-associated ovarian cancers, the cancer is adjacent to or directly arising from the endometriotic tissue, lending credence to the fact that malignant transformation can and does occur [Giudice et al]. Animal studies suggest that common molecular genetic pathways, specifically K-RAS/MAPK and PTEN/PI13, are involved in the pathogenesis of both endometriosis and endometrioid ovarian carcinoma. Still, epidemiological findings on the association between endometriosis and cancer remain elusive; however, providers from all disciplines should be aware of this increased risk profile and strive for early disease detection.
Dr. Michio Abe
Internal Medicine
2 doctors agree
In brief: Not known
There appears to be a link between endometriosis and ovarian cancer, but the causal relationship is not established.
I wouldn't dwell on the link aspect if you had endometriosis. Obesity, which is a more common problem, is much worse when it comes to cancer link. It's linked with many more forms of cancer, including colon, breast, endometrial, esophageal, pancreatic, gallbladder, kidney, thyroid.

In brief: Not known
There appears to be a link between endometriosis and ovarian cancer, but the causal relationship is not established.
I wouldn't dwell on the link aspect if you had endometriosis. Obesity, which is a more common problem, is much worse when it comes to cancer link. It's linked with many more forms of cancer, including colon, breast, endometrial, esophageal, pancreatic, gallbladder, kidney, thyroid.
Dr. Michio Abe
Dr. Michio Abe
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