3 doctors weighed in:

Are antidepressants potent antihistamines also?

3 doctors weighed in
Dr. Sudhir Gadh
Psychiatry
1 doctor agrees

In brief: Some are, yes.

Looking at receptor inhibition profiles (lab data) we can see that some do indeed block histamine receptors.
Older ones in the tca class (elavil, anafranil, etc), trazodone and even a more modern one like Remeron (mirtazapine) do so which can lead to increased sleepiness and appetite. As far as potency, they're not as effective as sudafed in fighting a cold.

In brief: Some are, yes.

Looking at receptor inhibition profiles (lab data) we can see that some do indeed block histamine receptors.
Older ones in the tca class (elavil, anafranil, etc), trazodone and even a more modern one like Remeron (mirtazapine) do so which can lead to increased sleepiness and appetite. As far as potency, they're not as effective as sudafed in fighting a cold.
Dr. Sudhir Gadh
Dr. Sudhir Gadh
Thank
Dr. Alan Ali
Psychiatry

In brief: AD's

Some antidepressents have anticholinergic/antihistaminic effects.

In brief: AD's

Some antidepressents have anticholinergic/antihistaminic effects.
Dr. Alan Ali
Dr. Alan Ali
Thank
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