2 doctors weighed in:

Can you take melatonin at the same time as benadryl (diphenhydramine)? i take benadryl (diphenhydramine) for allergies but im still having trouble sleeping, dont want to mix what i cant.

2 doctors weighed in
Dr. Linda Schwartz
Pharmacology
1 doctor agrees

In brief: Melatonin &Benadryl

You can take both melatonin and benadryl (diphenhydramine) together. They have different mechanisms of actions.
However, they will have a synergistic effect (more sedation, drowsiness). Avoid alcohol and driving. Tips to help with sleep. Avoid stimulants (i.e., caffeine). Get plenty of exercise. Avoid late eating. Make sleep environment relaxing (no reading, no tv).

In brief: Melatonin &Benadryl

You can take both melatonin and benadryl (diphenhydramine) together. They have different mechanisms of actions.
However, they will have a synergistic effect (more sedation, drowsiness). Avoid alcohol and driving. Tips to help with sleep. Avoid stimulants (i.e., caffeine). Get plenty of exercise. Avoid late eating. Make sleep environment relaxing (no reading, no tv).
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