My dr has me on low dose methotrexate, tramadol, Wellbutrin xr, buspar, (buspirone) Xanax and ambien. Are all these drugs safe together?

Comments. I would not be surprised to encounter drug-drug interactions here, which could enhance adverse effects, and even compromise intended efficacy. Not having a clue as to why you take any of these, I cannot advise further, but think you would do well to have an extensive discussion with your doctor about all of this.