2 doctors weighed in:

If I stop takeing betahistine even for a day the vertigo comes back also the prescribe dose no longer work I currently take 1 8mg tablet 3 times?

2 doctors weighed in
Dr. Sandra Lora Cremers
Ophthalmology

In brief: Vertigo

Usually in the US, we do an extensive study for vertigo before Rx meds.
Look into Vestibular rehabilitation & Canalith repositioning maneuvers if not tried. Otherwise, discuss med dosing with your MD.

In brief: Vertigo

Usually in the US, we do an extensive study for vertigo before Rx meds.
Look into Vestibular rehabilitation & Canalith repositioning maneuvers if not tried. Otherwise, discuss med dosing with your MD.
Dr. Sandra Lora Cremers
Dr. Sandra Lora Cremers
Thank
Dr. Dimitri Novitzky
Surgery - Thoracic

In brief: Betahistine, vertigo

It all depends of the 1/2 life in your body, you can safely increase the dose, providing the symptoms are under control.
Check with your DR. Biologic half- life of betahistine as determined by pharmacokinetic analysis is characterized by a high degree of variability (2-11 hours) with a mean of 5 hours. As a biologic effect in the brain is dependent upon the sustained availability of the active betahistine over a period of at least 6-12 hours it is crucial that an optimal formulation of betahistine exhibit a pharmacokinetic half-life (ti/2) greater than 5 hours and preferably 8-12 hours. Once or twice daily dosing could thereby achieve a sustained effect of betahistine to block brain histamine H3 Dose- and duration-dependent effects of betahistine dihydrochloride treatment on histamine turnover using a betahistine dihydrochloride formulation at oral doses roughly equivalent to those currently given to humans for Meniere's Disease (ie 24-48 mg/day), as well as 2 fold, 5 fold and 10 fold higher doses, found that to achieve a rapid biological effect on histamine H3 autoreceptors, 5 fold and 10 fold higher equivalent doses were required

In brief: Betahistine, vertigo

It all depends of the 1/2 life in your body, you can safely increase the dose, providing the symptoms are under control.
Check with your DR. Biologic half- life of betahistine as determined by pharmacokinetic analysis is characterized by a high degree of variability (2-11 hours) with a mean of 5 hours. As a biologic effect in the brain is dependent upon the sustained availability of the active betahistine over a period of at least 6-12 hours it is crucial that an optimal formulation of betahistine exhibit a pharmacokinetic half-life (ti/2) greater than 5 hours and preferably 8-12 hours. Once or twice daily dosing could thereby achieve a sustained effect of betahistine to block brain histamine H3 Dose- and duration-dependent effects of betahistine dihydrochloride treatment on histamine turnover using a betahistine dihydrochloride formulation at oral doses roughly equivalent to those currently given to humans for Meniere's Disease (ie 24-48 mg/day), as well as 2 fold, 5 fold and 10 fold higher doses, found that to achieve a rapid biological effect on histamine H3 autoreceptors, 5 fold and 10 fold higher equivalent doses were required
Dr. Dimitri Novitzky
Dr. Dimitri Novitzky
Thank
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