Is Apixaban 2.5 mg twice daily safe to be used for paroxysmal Afib in 72 yr hypertensive male with (s.creatinine1.7)? what is the safest anticoagulant

NothingPerfectlySafe. Always about weighing pros vs. cons, & always lots of guesswork. Best strategy: get SBP low normal (<120 mmHg) by dealing with human issues driving the ?BP +/- ACEI agents & carvedilol (amlodipine only if/when needed). This ?es stroke rates & progression of renal failure. A. Fib always ?es stroke rates, anticoag ?es this partially. Apixaban best newer agent at 5 mg bid, but 2.5 bid less effective.