I've been taking Prozac 10 mg for 20 years. Lorazepam 1 mg 3 times a day. Adding Wellbutrin (bupropion) is it safe?

These meds are ok. Together. Bupropion should not be taken if history of seizures. Bupropion may increase blood levels of prozaz so your prescriber will want to know if you experience increase in side effects. Best regards for good health.
MedicationDependence. Combining Wellbutrin (bupropion) with Prozac may increase the risk of seizures. Wellbutrin (bupropion) can increase the blood levels of Prozac which may increase other side effects. Discuss with Psychiatrist • Diagnosis of Anxiety, Depression or both • Severity of symptoms now needing medication • Dependence on medications • Therapy for stresses in your life • Breathing Relaxation • Visual Imagery • MeditationTai Chi.