Can lupus directly impact the brain? Myoclonic seizures, major depression, GAD, major mood swings. No official diagnosis, but positive for antibodies.

A few comments. Yes, lupus cerebritis can occur. Spinal fluid measure of P-ribosomal protein might help. Your myoclonic seizures could be Juvenile Myoclonic Epilepsy, and could benefit from Depakote or Keppra (levetiracetam). Your emotional state could be assessed by psychiatry. Recommend you see a neurologist, and have all of this looked at thoroughly.
Yes, consult your dr. Common symptoms of lupus include: profound fatigue, mental confusion, and seizures. Many people with a serious physical illness experience anxiety and depression while coping with their illness. The drugs used to treat lupus all have side effects, and it is difficult to separate these from the symptoms of illness. Check with your dr re ongoing treatment esp if you are considering pregnancy.