Can drinking 3 to 4 glasses of wine every other night while on Wellbutrin (bupropion) xl 150mg make Wellbutrin (bupropion) less effective on helping depression and how much?

Alcohol depresses. Alcohol, while possibly briefly making you happier, is a depressant with long term use. How much will it take to sabotage the effects of antidepressant medication is hard to say, as it varies by individuals. However, the amount you are talking about is not healthy, whether depressed or not. Discuss this with your treating doc and your therapist. Fastest response to medication & therapy? No booze.
Hasn't your doctor. advised medically against use of alcohol in this scenario? Can't give you a statistic about how certain amounts of alcohol can increase depression by certain amounts. Bottom line is that it looks like a # of doctors are tell you that this is not safe. It sounds like you have a problem with alcohol.

Related Questions

On 75 mg wellbutrin (bupropion) 2x day. Have 2-3 glasses of wine socially on occasion. Is it better to skip 2nd dose wellb those days? Want to be safe

Best is to avoid. Best is to avoid drinking its not only interact with medications also affect your mood it's not helping antidepressant to work effectively . Read more...
Use good judgement. Are you listening to yourself? You are considering not taking your prescribed medication so that you drink alcohol. Wellbutrin and alcohol can interact. See:,1034-14582. Your wellbutrin should be taken consistently. Read more...