2 doctors weighed in:

Which is better and more safe in general for treating hypertension and atrial fibrillation metoprolol succinate or bisoprololesp. If s.creatinine1.56 ?

2 doctors weighed in
Dr. Milton Alvis, jr
Preventive Medicine
1 doctor agrees

In brief: Neither. In clinical

trials, carvedilol has significantly better outcomes than either metoprolol (e.
g. 3%/yr lower mortality rates continuing for many years) or bisoprolol. Creatinine is quite another issue, produced by all muscle cells, yet used to crudely estimate renal filtering function, not the 4 known responses to carvedilol. Yet the clinical trial data for all the Beta blockers is as augmenters to ACEI agents.

In brief: Neither. In clinical

trials, carvedilol has significantly better outcomes than either metoprolol (e.
g. 3%/yr lower mortality rates continuing for many years) or bisoprolol. Creatinine is quite another issue, produced by all muscle cells, yet used to crudely estimate renal filtering function, not the 4 known responses to carvedilol. Yet the clinical trial data for all the Beta blockers is as augmenters to ACEI agents.
Dr. Milton Alvis, jr
Dr. Milton Alvis, jr
Thank
1 comment
Dr. Milton Alvis, jr
Far more important to the above issues is addressing all the know CVDs driving factors. Eg. LCHF foods (not visa versa) optimize (i.e. healthy, not normal) NMR lipoproteins (not cholesterol, wrong issue, routinely misleading), HbA1c 5.0%, Systolic BP <120 mmHg, don't smoke, etc. Study my many answers on Healthtap on these topics. I routinely see people progressively improve their health over time.
Get help from a real doctor now
Dr. Vicken Poochikian
Board Certified, Internal Medicine
39 years in practice
2M people helped
Continue
111,000 doctors available
Read more answers from doctors