Can topical clotrimazole cream be used vaginally as well? Only difference between the 2 seems to be the inactive ingredients.

Maybe OK, but why? The skin (non-vaginal) cream might work, but can't be guarantteed; I'm sure the manufacturer never studied it for vaginal yeast. And you'd need to use nearly an entire tube of skin cream for just 1-2 treatments. Clotrimazole vaginal cream is designed to be effective and generic versions often are cheap. Or consider a single oral dose of fluconazole (Diflucan®), which is just as effective.