Can bupropion interact with caffeine? Is it dangerous?

Additive side effect. They both can have an effect on heart rate and blood pressure. They both can increase anxiety and they both raise the possiblity of seizzures. So, i would very much minimize my caffiene intake, that includes coffee, chocolate, tea, soda, esp diet soda when taking wellbutrin (bupropion).
Yes. Most people find bupropion to be stimulating, even if mildly. Caffeine is also stimulating. Together they can be substantially stimulating and make you feel jittery.