Can Co2 fractional Laser help reduce the appearance of stretch marks?

It might work. Unfortunately, there is no simple stretch mark removal cream that works. Stretch marks fade over time, but are permanent, even if they become much less noticeable over time. Sometimes, dermatologists can help improve the appearance of stretch marks with laser or infrared therapy. One can get opinions from a couple of local dermatologists.
It could. There is no easy or magic way to make stretch marks disappear. The only thing that can be done as physicians is to improve their appearance. There are many methods today to improve them. You can try fractional CO2 resurfacing, radio frequency, IPL, etc. I recommend that you consult with a plastic surgeon or dermatologist in order to explore the possibilities.