How many diclofenac sodium 50 mg tablets can be taken at one time? Do I also take it every 6 or 8 hours?

Maximum dose. 100 mg by mouth 2 times a day. Always talk with your doctor about all medicines you take.
NSAIDS/Diclofenac. NSAIDS like diclofenac are best taken with food. If you have the 50mg dose, the regimen is 2 q12 max of 4in 24 hours.