How exactly do antidepressants work?

Antidepressant. Antidepressant medications work by balancing chemicals in the brain called neurotransmitters that affect mood and emotions. They affect certain brain circuits and neurotransmitters that pass along signals from one nerve cell to another in the brain. These chemicals include Serotonin, Dopamine, and Norepinephrine. These medications can help improve mood, sleep, appetite, interest and energy.