If I crush zofran (ondansetron) pill before swallowing will it work faster? If so by how much? Severe nausea comes on very quickly & zofran (ondansetron) takes too long to work.

Zofran (ondansetron) ODT. Zoran ODT(orally dissolvable tablets) dissolves quickly in saliva, doesn't require water to swallow, and thus works faster than Zofran (ondansetron) tablets.
Zofran (ondansetron) There is an orally disintegrating form ( Zofran ODT) and thin stripas well as the liquid which may have oral absorption. Zofran is not on the ISMP list of do not crush ,so it should be OK but take with a glass of water. Avoid in long QT syn. If pregnant Phenergan (promethazine) is better, zofran does have birth defect (FDA) www.ismp.org/tools/donotcrush.pdf http://www.rphworld.com/viewlink-25324.html.