I'm 37 & take 10mg Prozac & 40mg vyvanse (lisdexamfetamine). Plus 100mg of unisom. Over several mths I feel exhausted at the fact that I have to live. Normally I'm jolly?

Drug review. Sounds like you need to speak with your provider to see if those meds are potentially part of the problem or if the regimen needs to be adjusted. Looking at your individual genetics can help fine tune medications as well as seeing what interventions other than medication (diet, supplements) will help. Looking at hormone levels is also key. Finding a good therapist can also be very helpful.