Bitten by insect on lower leg in 4 sites. Swells red (thumb size) with brown center and itches. Treatments thus far contain but don't cure. Advice?

I don't know. what you mean by "CURE"....Local antibiotic/antiitch creams may help but "TINCTURE OF TIME" is the only "CURE"! If there is INFECTION however a systemic antibiotic may be needed. Call your Primary Care Provider as soon as practicable! Hope this helps! Dr Z.