8 doctors weighed in:

I take klonopin .5 a day and Wellbutrin (bupropion) 150mg twice a day I can't sleep is it safe to add doxylamine succinate aka unisom with that mix?

8 doctors weighed in
Dr. Patricia Foster
Psychiatry
5 doctors agree

In brief: Drug interactions

Doxylamine is an antihistamine which may interact with Klonopin (clonazepam) to increase side effects such as dizziness, drowsiness or difficulty concentrating.
Limit or avoid use of alcohol and avoid driving until you know how this combination of medications affect you. Discuss with your prescribing doctor before taking Unisom. Take care.

In brief: Drug interactions

Doxylamine is an antihistamine which may interact with Klonopin (clonazepam) to increase side effects such as dizziness, drowsiness or difficulty concentrating.
Limit or avoid use of alcohol and avoid driving until you know how this combination of medications affect you. Discuss with your prescribing doctor before taking Unisom. Take care.
Thank

In brief: Depends

If your physical condition is OK , there are no other meds involved and you don't have side effects especially tiredness or hangover during the day , it should not be a problem. However, you may want to look into the possibility that there are emotional or psychological reason related to your insomnia which might benefit by therapy.

In brief: Depends

If your physical condition is OK , there are no other meds involved and you don't have side effects especially tiredness or hangover during the day , it should not be a problem. However, you may want to look into the possibility that there are emotional or psychological reason related to your insomnia which might benefit by therapy.
Thank
Dr. Umee Davae
Psychiatry

In brief: Yes - with low doses

Ok to take doxylamine but avoid more than 25mg.
It is a sedating anti-histamine (like benadryl). Do not take if operating machinery / driving. You may be drowsy in the AM so take it early before bed. It is prudent to avoid long term use. Also, make sure your second dose of Wellbutrin (bupropion) is no later than 2pm since Wellbutrin (bupropion) itself can promote wakefulness. Avoid taking with higher doses of Klonopin.

In brief: Yes - with low doses

Ok to take doxylamine but avoid more than 25mg.
It is a sedating anti-histamine (like benadryl). Do not take if operating machinery / driving. You may be drowsy in the AM so take it early before bed. It is prudent to avoid long term use. Also, make sure your second dose of Wellbutrin (bupropion) is no later than 2pm since Wellbutrin (bupropion) itself can promote wakefulness. Avoid taking with higher doses of Klonopin.
Thank
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