FDA upgrading heart/stroke risk on OTC NSAIDs, Tylenol (acetaminophen) can affect liver. What else is there for occasional pain/inflam relief? Is aspirin only choice?

No free lunch. There's no such thing as a free lunch. In other words, there're always some potential risks or side effects. If dietary supplement manufacturer claims no risks or side effects b/c it's natural, herbal, organic, gluten-free, then avoid it b/c they're lying. Acetaminophen can irritate liver but only if excessive dose. NSAIDs can increase heart attack risk but not guarantee that you'll suffer one.