Do you need to? The first question I must ask is why do you feel you need both? Have you tried either one alone? Did your doctor advise the combination? You should let your doctor know your plans since melatonin could combine with OTHER drugs you could be taking that you didn't mention and that could be problematic. If you'd like to drop me a line and we can talk more: www. Healthtap. Com/drsaghafi.