So, I have been taking my new upped dosage of clexa (40mg) for almost a month now, and not much change. On my period again and depressed feelings back?

SSRI. Most SSRI manufacturers advise it will be 4-6 weeks before noticing the full effect, and if you increase dose, we are looking at another 4-6 weeks for that effect. But if you specifically have Premenstrual Dysphoric Disorder, the dx is very specific on the days in the cycle, and not just anywhere around your period. Great mood tracker at http://mymonthlycycles.com/pms_tracker.jsp Pls check w/doc.