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Sister is MTHFR positive. Homozygous w/ 2 abnormal copies of c677t. So one from mom & dad. What are my odds of not having, being hetero or homozygous?

1 doctor weighed in
Dr. Richard Roberts
Clinical Genetics

In brief: Possibly ¼ for not

Because your mother does not have a normal gene, she can only make eggs with a single copy of c677t, so you will receive one.
If your father is heterozygous, your chance of being heterozygous is 50%; if homozygous,, you will be too. Consult a board certified clinical geneticist who will inform you of the evidence-based facts with regard to possible risks. There is much nonsense on the internet.

In brief: Possibly ¼ for not

Because your mother does not have a normal gene, she can only make eggs with a single copy of c677t, so you will receive one.
If your father is heterozygous, your chance of being heterozygous is 50%; if homozygous,, you will be too. Consult a board certified clinical geneticist who will inform you of the evidence-based facts with regard to possible risks. There is much nonsense on the internet.
Dr. Richard Roberts
Dr. Richard Roberts
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