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If there is a cross- reactivity during an elisa test is it possible to end up with a false negative as a result?

5 doctors weighed in
Dr. Anne Phelan-adams
Family Medicine
4 doctors agree

In brief: False positives

Cross-reactivity can cause false positives (meaning that the test is positive but the actual substance tested for isn't there).
The happens when an antigen (virus, protein or bacterium) is so similar structurally that it reacts with the same antibody that the test is designed for. For example, the antibody test for latex allergy can sometimes cross react with a protein in bananas! Crazy, huh?

In brief: False positives

Cross-reactivity can cause false positives (meaning that the test is positive but the actual substance tested for isn't there).
The happens when an antigen (virus, protein or bacterium) is so similar structurally that it reacts with the same antibody that the test is designed for. For example, the antibody test for latex allergy can sometimes cross react with a protein in bananas! Crazy, huh?
Dr. Anne Phelan-adams
Dr. Anne Phelan-adams
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