Can a man have no sperm and if so what if any medication or method can be use or perform to help increase his count?

See remark. There are many causes for absence of sperm 1 Hormonal 2 problem with the testis 3 problem with the tubes/passages allowing the sperm to travel from the testis to the outside (ejaculation) Only a thorough exam by a urologist can ascertain the problem.
Infertility. Condition is called azospermia. It is usually associated with testicular failure and makes a man infertile. Semen analysis and blood tests will be able to help establish the diagnosis. .