Hi! Can we possibly look at replacing clonidine with melatonin? My son takes Lexapro (escitalopram) due to anxiety and is on the autism spectrum...

Work with doctor. Clonidine and Melatonin are very different drugs, not interchangeable. You need to speak to his doctor about your specific concerns. The doctor may be giving him a particular regiment for a particular reason. Do not play with the medications without involving the supervising doctor.