Why does wellbutrin (bupropion) cause the side effect of inflammation in 1 feet (redness and swelling) within a day or two of use?

Concurrent Rx. Perhaps it's an interaction between Wellbutrin (bupropion) and another medication or herbal that you are taking. Do you have any other medical conditions ? Does the inflammation persist throughout the entire time that you are taking Wellbutrin (bupropion) ? Is this the first time that you have taken Wellbutrin (bupropion) ?