Do ppi drugs quit working? I have been on aciphex (rabeprazole) for over a year and the heartburn and sore throat is back.

See gastroenterology. Proton pump inhibitors do not stop working, but there may be other reasons for your heartburn to return. You should see a gastroenterologist for an upper endoscopy to rule other causes of heartburn, such as hiatal hernia, esophageal spasm or achalasia, gastric ulcer, esophagitis, gastritis. Also coronary artery disease can mimic GERD, but you are young for this.