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The interaction between klonopin (clonazepam) and tegretol:tegretol lowers klonopin (clonazepam) by 30% -does klonopin (clonazepam) raise tegretol ?

1 doctor weighed in
Dr. Rick Barnett
Clinical Psychology

In brief: Not great combo

Concomitant administration of clonazepam (Klonopin) and carbamazepine (Tegretol) resulted in a 22% increase in clonazepam clearance and a 20.
5% decrease in carbamazepine clearance. Carbamazepine is well known to induce its own metabolism as well as the metabolism of other meds making it difficult to manage. Consult provider. Bottom line - Klonopin is not likely to raise Tegretol levels.

In brief: Not great combo

Concomitant administration of clonazepam (Klonopin) and carbamazepine (Tegretol) resulted in a 22% increase in clonazepam clearance and a 20.
5% decrease in carbamazepine clearance. Carbamazepine is well known to induce its own metabolism as well as the metabolism of other meds making it difficult to manage. Consult provider. Bottom line - Klonopin is not likely to raise Tegretol levels.
Dr. Rick Barnett
Dr. Rick Barnett
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