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Um how do I explain the effect of Addison's disease to the integumentary system?

2 doctors weighed in
Dr. Alan Feldman
Internal Medicine - Endocrinology
1 doctor agrees

In brief: Skin darkening

Addison's disease (primary adrenal insufficiency) is associated with high ACTH levels from the pituitary gland.
Other hormones are also made from the pituitary (MSH) that can stimulate melatonin production in the skin, causing skin darkening (similar to a suntan)

In brief: Skin darkening

Addison's disease (primary adrenal insufficiency) is associated with high ACTH levels from the pituitary gland.
Other hormones are also made from the pituitary (MSH) that can stimulate melatonin production in the skin, causing skin darkening (similar to a suntan)
Thank
1 comment
Dr. Alan Feldman
Correction for above: melanin not melatonin