1 doctor weighed in:

Are diphenhydramine and Zoloft (sertraline) bad to take together?

1 doctor weighed in
Dr. Edward Kuhnley
Pediatrics - Psychiatry

In brief: OK but Caution

Benadryl (diphenhydramine) together with sertraline may increase side effects such as dizziness, drowsiness, & difficulty concentrating.
Some people may also experience some impairment in thinking & judgment. You should avoid/limit use of alcohol while being treated with these medications. Avoid driving or operating hazardous machinery until you know how the medications affect you. Max Benadryl (diphenhydramine) dose is 300mg/d.

In brief: OK but Caution

Benadryl (diphenhydramine) together with sertraline may increase side effects such as dizziness, drowsiness, & difficulty concentrating.
Some people may also experience some impairment in thinking & judgment. You should avoid/limit use of alcohol while being treated with these medications. Avoid driving or operating hazardous machinery until you know how the medications affect you. Max Benadryl (diphenhydramine) dose is 300mg/d.
Dr. Edward Kuhnley
Dr. Edward Kuhnley
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