2 doctors weighed in:

Is it possible that Zantac, being a histamine blocker, could cause higher histamine production when coming off of it, resulting in development of allergies? For example consuming diet soda can result in insulin spikes in some cases, possibly leading to di

2 doctors weighed in
Dr. John Chiu
Internal Medicine - Allergy & Immunology
1 doctor agrees

In brief: No

Zantac (ranitidine) is a histamine 2 receptor reverse agonist and would not significantly affect histamine production.
when withdrawn. There is a theoretical possibility that Zantac (ranitidine) itself may lead to more histamine release by blocking the histamine 2 receptor(which acts as a feedback switch) but this has not been clinically a significant issue.

In brief: No

Zantac (ranitidine) is a histamine 2 receptor reverse agonist and would not significantly affect histamine production.
when withdrawn. There is a theoretical possibility that Zantac (ranitidine) itself may lead to more histamine release by blocking the histamine 2 receptor(which acts as a feedback switch) but this has not been clinically a significant issue.
Dr. John Chiu
Dr. John Chiu
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