Can I take Nitrofuratoin and nyquil?

Yes. The two drugs do not interfere with each other. Nyquil contains a pain reliever, a cough suppressant, and an antihistamine. Nitrofurantoin is an antibiotic mostly used for bacteria infection in the bladder. It is ok to take both drugs together.
No sig interaction. Nyquil contains acetaminophen (tylenol), dextromethorphan (cough suppressant), and doxylamine succinate (antihistamine). Nitrofurantoin is an antibiotic commonly prescribed for bladder infections. There are no known drug-drug interaction between the two meds.