Does pernicious anemia cause high serum b12?

Low vitamin B12. pernicious anemia is a LOW vitamin B12 state. This occurs when the body fails to make enough of a specific protein to enable the body to absorb vitamin B12. This usually occurs when the immune system attacks a specific cell in the stomach that produces the needed protein. Since the body can't absorb vitamin B12 through the stomach it can be given in a shot and even under the tongue.

Related Questions

Hematocrit normal but got high MCV. Could having pernicious anemia be the cause of my long term panic disorder? B12 produces neurotrans. Through methylat

Possibly. Low B12 leading to pernicious anemia will cause MCV to rise as can folic acid and thryoid disease. Alcohol related blood dyscrasia can elevate MVC, as can other types of liver disease. If you hemaglobin/hematocrit is normal that pretty much rules out pernicious anemia unless very early stages. http://emedicine.medscape.com/article/203858-overview#a0104 Recommend some additional testing. Read more...
Could be. but isn't. a b12 level will confirm that the amount in your system is more than adequate. b12 is in all animal products and is stored for months. Deficiencies occur: in the elderly with very thin absorption areas in the gut that can't get it in. rare parasitic diseases total hardcore Vegans. Read more...

What is the actual cause of B12 (cyanocobalamin) deficiency in the body in pernicious anemia?

No intrinsic factor. B12 in the diet usually binds to intrinsic factor in the stomach and then gets absorbed by the small bowel. In pernicious anemia, there is low or no intrinsic factor being made by the stomach cells. As a result, there is gradual deficit of B12 stores and eventaully as all the B12 is gone the new red blood cell production is affected. Read more...

B12=262 & muscles have gotten weak in the past month. Grandmother and great grandmother both had pernicious anemia and/or B12 def. Cause for concern?

Yes. All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, your B12 level is just at the lower limit of normal. Your family history does put you at risk for B12 deficiency. It can be corrected with B12 injections at one to 3 month intervals. It would be prudent to consult your doctor. Read more...

What would cause low ferritin (13 last yr, now 9) if RBC indices are normal & so is iron panel? Thyroid ok. I take IM B12 for pernicious anemia. 28f

Early deficiency. Serum ferritin drops off before anemia appears or red cell indices go abnormal. Your physician will ask you about diet, your cycle, and whether you're perhaps having blood loss via the gut -- he / she will check. If you are a non-supplementing vegetarian, please reconsider. Best wishes. Read more...

I'm curious what could happen to people who have pernicious anemia but are intolerant to b12?

Vit b12. if you have pernicious anemia- and you do not take replacement of vit B12- your vitamin b12 obviously will continue to go down . anemia, weakness, fatigue, memory problem, forgetfulness , neuropathy, dementia can happen with significant vitamin b12 deficiency- and those can become permanent if you do not take supplement of vit b12. what do you mean by intolerance? you can get via IM, sublingual . Read more...
You need B12. If you have pernicious anemia, you need to take Vitamin B12 because your body does not absorb this vitamin. Vitamin B12 is a water-soluble vitamin that is usually very well tolerated, and non-allergenic. In patients that have pernicious anemia, B12 is usually given intramuscularly by injection once a month, and many patients administer it to themselves. It can also be given intranasally. Read more...

What else can help with pernicious anemia other than b12 injections? Have read that in UK the type of b12 used in injections isn't very good. True?

Bunk. Stop reading internet disinformation. Back in the old days, pernicious anemia assured a terrible lingering death preceded by insanity. The very fact that "natural healing" types make up stuff about the injections that have saved millions of lives show how successful they are. Forgive my frankness and remember that the law requires your physician to be honest while crooks have no accountability. Read more...

What's the difference between pernicious anemia and B12 anemia?

See below. B-12 anemia is a deficiency in vitamin b-12 (cobalamin). Pernicious anemia is a deficiency or lack in intrinsic factor (produced by cells in the stomach) which is a protein essential for absorption of vitamin B12 in the ileum (small intestine). Pernicious anemia requires replacement of intrinsic factor &/or b-12. B-12 anemia needs only b-12 supplementation. Read more...