Would taking B-Complex, D3, E, and a C vitamin daily be safe? I take atenolol 25mg and lisinopril 20mg for high blood pressure. M/25/5'8'' 280lbs

Yes, they are safe. It is best to take B-complex vitamins with breakfast in the morning since they provide lots of energy. Vitamins E and C should always be taken together after a meal since vitamin C keeps vitamin E in an antioxidant state. Vitamin D can be taken at any time of the day and has many benefits.
Combination. That combination should be safe. I presume you're doing something about your weight at 5'8" and 280lb.