Will avastin (bevacizumab) increase survival significantly for metastic colon cancer with liver mets? Is it a risky drug

Slight benefit. Bevacizumab (Avastin (bevacizumab)) is one of those drugs that is extremely expensive and often has limited benefit. Patients with metastatic colon cancer who received Avastin (bevacizumab) plus chemotherapy lived 1-2 months longer on average than those receiving chemo only. Because it has marginal benefit but costs ~$30,000 the U.K. Health Service won't pay for it. It can cause skin rash, bleeding or wound healing problems.

Related Questions

Hubi had colon cancer 2yrs ago now has 40% liver mets 2 at 4" and 14 smaller ones had 3 months oxi p no improvement now on avastin (bevacizumab) and oxi how long?

Depends. We don't have expiration date marked on our body. How long one will live will depend on many factors. It will definitely depend on the biology of the cancer, the response to therapy, your husband's overall condition etc.At least from studies we know, on average, stage IV colon cancer's survival is approximately 36 months or so. One may be shorter while other may be longer. D/w your oncologist. Read more...

If SIRT is done for liver mets, can this significantly prolong survival in metastic colon cancer pt?

Yes. It is palliative not curative. The amount of life extension is based on each individual case. Read more...
In the right patient. Yes, in the appropriate clinical setting of 2nd, 3rd line and salvage therapy. Selective internal radiation therapy (SIRT/Y-90) is recommended for chemorefractory disease with liver-only or liver-predominant disease & in people who do not wish to have systemic chemotherapy. Since the median survival in failed 3rd line chemo patients is in the range of 4-6?mth, SIRT can extend survival to 10-12 mth. Read more...

Can TACE be done on the liver for liver mets if there are peritoneal mets for metastic colon cancer?

Yes. But probably not advised since peritoneal mets are more rapidly fatal than liver mets. Has your oncologist suggested intra-abdominal installation of chemotherapy This article may help http://jjco.oxfordjournals.org/content/31/12/571.full. Read more...

10 liver mets and a node in metastic colon cancer. Xeloda (capecitabine) irinitecan failed. Can anything be done?

Yes. When colon Ca metastasizes to the liver it remains and progresses there with occasional node to porta. The first approach is to try chemoembolization after having an angiogram of the hepatic artery. This route can also be used for intrahepatic isotope administration. Systemically chemo plus avastin (bevacizumab) or Erbitux can be tried. New studies with Neo 102 are being offered in FDA trials . Read more...

Is avastin (bevacizumab) a good treatment for metastic colon cancer? Are the side effects harsh?

GOOD MEDICINE. avastin (bevacizumab) indicated for first line and second line treatment for metastatic colorectal carcinoma in combination with 5-Fluorouracil based chemotherapy side effect is long like weakness,hypertension,vomiting you can google the medicine and you can get the long list follow with your oncologist good luck. Read more...

How effective is the IFL-Bevacizumab chemotherapy regimen for treating colon cancer?

Better than chemo. Combining bevacizumab (BV)—a recombinant, humanized mAb targeting VEGF with irinotecan, fluorouracil (FU), and leucovorin (LV; IFL) has increased survival of patients with metastatic colorectal Ca compared with IFL It appears necessary to use combination therapy in treatment and has supported the concept that the use of immunochemotherapy improves results over chemo alone. Read more...