What causes ureidopropionase deficiency? Also is it any harm to the health? What are the signs and symptoms in someone who is deficient?

Mutations in the . UBP1 gene on Chromosome 21q11.3 cause deficiency in beta-ureidoproprionase, 1 of 3 enzymes in the liver that degrade pyramidines It's a very rare inborn error of metabolism that causes biochemical abnormalities & clinical signs that range from Intellectual Disability, multiple congenital anomalies & seizures to normal neurological development, depending on the mutations in the UBP1 gene. .