Is Diflucan (fluconazole) 100mg pill safe for the liver? I need to take it for 6 months for toenail fungus. 2 pills weekly one month, then 1 weekly.

If taken properly. All oral anti fungal medications can cause liver toxicity. That is why your Liver enzymes are monitored monthly for any changes. There are less toxic drugs on the market. PO lamisil (terbinafine) and Sporonox which can be taken in a pulse dose format.